A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles.
نویسندگان
چکیده
An efficient and general palladium-catalyzed coupling of 3-chloro-quinoxalinones with a variety of nitrogen-containing nucleophiles such as (hetero)aromatic and aliphatic amides as well as some challenging weakly nucleophilic nitrogen compounds including lactams, carbamates and NH-containing azoles is described. In all cases, the reactions take place rapidly and cleanly in dioxane using Pd(OAc)2 as a catalyst, Xantphos as a ligand and K2CO3 as a base furnishing the coupling 3-N-substituted quinoxalinone products in good to excellent yields.
منابع مشابه
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 23 شماره
صفحات -
تاریخ انتشار 2013